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“Researchers are studying whether consumption of the exogenous ketone ester, beta-hydroxybutyrate, may confer some of the health advantages of a ketogenic diet through its activation of PPAR-alpha, a key enzyme in the fasting response.”

“In turn, cellular levels of nicotinamide adenine dinucleotide, or NAD+, a coenzyme that participates in the production of cellular energy, rise, switching on energy-generating pathways and activating enzymes such as sirtuins.”

Dr. Rhonda Patrick discusses Akkermansia muciniphila, vitamin B1's effect on blood sugar, emulsifiers in food, and electrolyte supplements.

“In this clip, Dr. Valter Longo describes how a fasting-mimicking diet can reduce markers of inflammation, such as C-reactive protein and Interleukin-6, possibly by killing damaged cells and regenerating others and resetting the system back to a more youthful state.”

“Although scientists have identified other lifestyle behaviors that can help prevent the build-up of amyloid plaques by boosting the capacity for glymphatic clearance – such as exercise and adequate intake of omega-3 – the most important factor by far is a good night's sleep, especially deep sleep.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“In this FoundMyFitness interview clip, Dr. Peter Attia explains that early detection can reduce the burden of disease available to mutate and evade treatment, but screening carries financial, procedural, and false-positive harms.”

“More than four decades of study in the field of aging research have yielded some impressive findings, the most significant of which was the identification of longevity genes that are present in nearly every life form on earth.”

“Longer endurance aerobic exercise seems to be most effective at producing higher levels of FGF21, coinciding with anecdotes you might have heard from runners who have successfully used exercise in this sort of way. Relevant publications Flippo, Kyle H., et al.”

“In the modern-day with no imposed fasting, these cycles of renewal may remain dormant. In this clip, Dr. Valter Longo discusses how cellular repair mechanisms may have evolved during times of fasting, but are latent in times of food abundance.”