Related Episodes for Dr. David Sinclair’s personal dosage and supplementation habits | David Sinclair

“This is a personal preparation example, not the high-dose oat regimen used in clinical research or a measured 3-gram beta-glucan serving. For the research on LDL cholesterol, microbial metabolites, and oat preparation, see Oats and beta-glucan.”

Dr. Rhonda Patrick discusses iron imbalances, urolithin A, NAD+ boosters, vitamin K2 and hormone replacement therapy in women.

“The discussion of fiber and nutrient or supplement absorption begins at 19:38. The Oats and beta-glucan topic provides the wider cholesterol evidence and explains why whole oats, beta-glucan powder, and psyllium should not be compared solely by their serving weights.”

Dr. Rhonda Patrick discusses urolithin A, postmenopausal protein, microplastics, high-temperature saunas, sugar intake, and supplements for Parkinson's disease.

“In this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, the mechanisms behind how it works, and the bottom line on resveratrol supplementation and safety. A few key moments... For a more in-depth timeline, as well as references for this episode, click the timeline tab. Learn more about resveratrol on our overview page”

“In a randomized trial of 80 adults with overweight who usually slept fewer than 6.5 hours, counseling increased sleep by about 1.2 hours per night and reduced objectively measured energy intake by approximately 270 calories per day over two weeks.”

“Human trials suggest that alpha-lipoic acid can modestly improve selected lipid measures. A dose-response meta-analysis of 12 studies found reductions in total cholesterol, LDL cholesterol, and triglycerides across doses from 300 to 1,200 milligrams per day.”

“A 12-month randomized controlled trial found that vitamin D supplementation improved cognitive function, intelligence quotient scores, telomere length, and lowered oxidative stress markers in older adults with mild cognitive impairment (compared to placebo), suggesting that not only does vitamin D supplementation improve biomarkers of aging, but also functional outcomes.”

“A 2025 meta-analysis found improved quality of life, no clear overall change in ejection fraction, and a borderline improvement in New York Heart Association functional class across a small set of trials.”

“A meta-analysis restricted to direct regional measures from MRI, CT, or ultrasound found a very small average hypertrophy benefit when creatine was combined with resistance training, with uncertainty around the pooled estimate and variation across sites and populations.”