Why keeping NR & NMN supplements cold is crucial | David Sinclair
Two NAD+ precursors, nicotinamide riboside and nicotinamide mononucleotide, have been shown to ameliorate age-associated diseases in animals. They are well-tolerated at high doses and effectively raise NAD+ levels. These molecules are not shelf-stable at high temperatures or in conditions of high humidity, however. They quickly degrade into nicotinamide, which inhibits the activity of sirtuins and PARP, a DNA repair enzyme. In this clip, Dr. David Sinclair discusses the stability issues encountered with nicotinamide riboside and nicotinamide mononucleotide.
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