NAD+
NAD+ featured article
Nicotinamide adenine dinucleotide (NAD+) is a cofactor (a molecule that assists enzymes in chemical reactions) that plays an essential role in multiple physiological processes, such as energy metabolism, DNA repair, and immune activation. It is necessary for the activity of sirtuins, a class of enzymes involved in longevity, and poly-ADP-ribose polymerases (PARPs), a family of DNA-repair enzymes. Cellular NAD+ production declines with age, however, and its depletion likely drives the onset and progression of multiple age-related conditions such as metabolic dysregulation and neurodegenerative disease.
The human body can synthesize NAD+ from a variety of dietary sources, including tryptophan (an amino acid) and the three forms of niacin (vitamin B3) – nicotinamide (NAM, also called niacinamide), nicotinic acid (NA), and nicotinamide riboside (NR) – commonly referred to as niacin equivalents. Of these three, NA is the primary source of NAD+. These precursors are not equally...
Episodes
Dr. Rhonda Patrick discusses iron imbalances, urolithin A, NAD+ boosters, vitamin K2 and hormone replacement therapy in women.
Dr. Rhonda Patrick explores collagen peptides, high-dose niacin and vitamin B6, avoiding nano- and microplastics in her latest Q&A.
Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Dr. Rhonda Patrick discusses iron imbalances, urolithin A, NAD+ boosters, vitamin K2 and hormone replacement therapy in women.
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Dr. Rhonda Patrick explores collagen peptides, high-dose niacin and vitamin B6, avoiding nano- and microplastics in her latest Q&A.
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Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Rhonda Vitamin D Exercise Brain Alzheimer's Parkinson's Cancer Microbiome Cholesterol Omega-3 Skin Sulforaphane Protein NAD+ Moringa Blood-Brain Barrier CocoaDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Rhonda Vitamin D Exercise Obesity Vitamin C Pregnancy Muscle Sulforaphane Sauna Time-Restricted Eating Blood Sugar Weight Loss NAD+Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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In this clip, Dr. Patrick talks about the effects of nicotinamide mononucleotide on cancer growth.
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Rhonda Aging Breast Cancer Omega-3 Probiotics Coffee Vitamin B12 Vaccine Vitamin K Skin Sulforaphane Sauna Time-Restricted Eating Protein COVID-19 NAD+ Moringa SupplementsDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Rhonda Alzheimer's Gut Sleep Omega-3 Inflammation Vaccine Vitamin K Autism Sauna COVID-19 NAD+ SupplementsDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Rhonda Vitamin D Brain Cancer Epigenetics Aging Hormones Diabetes Vitamin C Antibiotics Vitamin K Sulforaphane Sauna Glutathione Oxidative Stress NAD+ CardiovascularDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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In this clip, Dr. David Sinclair describes his personal resveratrol and nicotinamide mononucleotide supplementation habits.
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In this clip, Dr. David Sinclair discusses the economic issues associated with research using nicotinamide riboside and nicotinamide mononucleotide.
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In this clip, Dr. David Sinclair discusses the current state of research on nicotinamide mononucleotide.
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In this clip, Dr. David Sinclair discusses the stability issues encountered with nicotinamide riboside and nicotinamide mononucleotide.
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In this clip, Dr. David Sinclair describes the NAD+ salvage pathway and how boosting cellular NAD+ levels may be beneficial in slowing aging.
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In this clip, Dr. David Sinclair describes the role of NAD+ in the regulation of the body's circadian clock and sirtuin production.
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Rhonda Exercise Cancer Sleep Omega-3 Probiotics Fasting Pregnancy Coffee Melatonin Sauna Vegetarian Time-Restricted Eating Breast Milk Senescence Metformin NAD+Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Rhonda Omega-3 Fasting Circadian Rhythm Mushroom Sugar Sauna Saturated Fat Vegetarian Protein Dairy NAD+ Cardiovascular SupplementsDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
Topic Pages
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NAD+
NAD+ is a ubiquitous redox cofactor that cycles between oxidized and reduced forms to shuttle hydride ions.
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Nicotinamide mononucleotide
Nicotinamide mononucleotide is an obligate NAD+ biosynthetic intermediate, enzymatically adenylylated by NMN adenylyltransferase to form NAD+.
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Nicotinamide riboside
Nicotinamide riboside is phosphorylated by NRK to NMN, then adenylated by NMNAT to restore intracellular NAD+.