Episode archive

Posted on November 2nd 2022 (about 1 month)

When people exercise as part of a treatment for alcohol abuse disorder it reduces their volume of alcohol consumption. But why? One reason may be FGF21.

Posted on August 23rd 2022 (3 months)

In this episode, George Church, Ph.D., one of the world's leading geneticists, discusses his work on how revolutionary technologies such as multiplex genome editing and genome writing could advance human health.

Posted on July 20th 2022 (5 months)

Lifestyle factors and new technologies offer the promise of living longer, healthier lives, but is there a limit to the human lifespan? This episode explores the different theories supporting this hotly debated topic.

Posted on June 29th 2022 (5 months)

In this episode, Dr. Stuart Phillips discusses the roles exercise and nutrition play in influencing human skeletal muscle protein turnover and highlights the importance of maintaining muscle mass and strength throughout the lifespan.

Posted on May 30th 2022 (6 months)

In this keynote address, Dr. Rhonda Patrick describes how the loss of health and integrity of the intestinal barrier influences multiple aspects of human health – including cardiometabolic function, neurological health, behavior, and more.

Posted on April 28th 2022 (7 months)

In this episode, Dr. Dominic D'Agostino, a world-class researcher and ketogenic diet practitioner, discusses how ketones affect exercise performance, reduce inflammation, and improve neurological health.

Posted on April 13th 2022 (8 months)

This episode features a discussion with MedCram co-founder Kyle Allred about all things sauna. From sauna's use as an exercise mimetic to its anti-inflammatory, mood-elevating, and detoxifying properties.

Posted on April 11th 2022 (8 months)

Morgan Levine, Ph.D., is a founding principal investigator at Altos Labs and an assistant professor of pathology at the Yale University School of Medicine.

Posted on April 1st 2022 (8 months)

In response to cold-water immersion, the body increases circulation of norepinephrine. This physiological response sets off a cascade of adaptive effects that affect metabolism, the brain, and genetic expression.

Posted on March 9th 2022 (9 months)

Peter Diamandis, MD and Tony Robbins are entrepreneurs and authors of "Life Force," a book on precision medicine and health technology.

Posted on February 8th 2022 (10 months)

The work on Eran Elinav, MD, PhD focuses on understanding the complex interactions between humans and the bacteria that reside in their gut and how these interactions shape human health and disease.

Posted on December 28th 2021 (11 months)

Research suggests psilocybin may have effects therapeutic for depression. In this episode, we discuss some of the qualities of the psychedelic experience that most lend psilocybin to be potentially therapeutically beneficial for depression.

Posted on December 7th 2021 (12 months)

Dr. Bill Harris is one of the world's preeminent experts in the field of omega-3 fatty acid research. His work focuses on the roles that fatty acids play in cardiovascular and neurocognitive health.

Posted on November 2nd 2021 (about 1 year)

Dr. Ashley Mason is a clinical psychologist whose research focuses on sauna use for depression and director of the Sleep, Eating, and Affect Laboratory at the Osher Center for Integrative Medicine at UCSF.

Posted on October 6th 2021 (about 1 year)

In this episode, Dr. Mark Mattson discusses how stress is beneficial – even essential – to human survival, and how exercise and intermittent fasting induce stress to promote health.

Posted on September 27th 2021 (about 1 year)

This is a special episode bringing you up-to-date science on COVID-19 vaccination featuring a conversation between Dr. Rhonda Patrick and MedCram founders Dr. Roger Seheult and physician assistant Kyle Allred.

Posted on August 18th 2021 (over 1 year)

Compared to people with the lowest blood concentrations of EPA and DHA (combined), those with the highest blood concentrations were as much as 17 percent less likely to die from all causes of premature death.

Posted on June 15th 2021 (over 1 year)

The work of Dr. Satchidananda Panda and his lab focuses on chronobiology, the study of the day-night cycles that drive the multifaceted activities of the human body, using genetic, genomic, and biochemical approaches.

Posted on May 24th 2021 (over 1 year)

Dr. Michael Snyder discusses the future of personalized medicine through the use of technology like continuous glucose monitor "big data" smart analytical techniques.

Posted on April 14th 2021 (over 1 year)

In this short video, Dr. Rhonda Patrick describes one of the mechanisms that drives the beneficial effects of sleep on the brain.

Posted on February 3rd 2021 (almost 2 years)

Dr. Roger Seheult is the co-founder of MedCram Videos, a frontline pulmonologist, and quadruple board-certified physician whose COVID-19 insights have garnered millions of views on YouTube.

Posted on December 18th 2020 (almost 2 years)

Consistent patterns of age-based alterations in DNA methylation can be harnessed to estimate age, serving as a sort of "clock," the premise of which is truly remarkable: Predict a person's age (or even lifespan), based on chemical modifications to their DNA that reflect the biological life history of the organism. Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan. In this episode, Dr. Steven Horvath describes epigenetic clocks and their role in predicting – and possibly slowing – aging.

Posted on December 11th 2020 (almost 2 years)

Dr. Steve Horvath found a way to measure biological aging – a type of "clock" – based on the methylation pattern of an organism's genome. This video primer explains the basics of epigenetic clocks, the topic of our interview with Dr. Steve Horvath.

Posted on November 16th 2020 (about 2 years)

Broccoli sprouts contain more glucoraphanin, the precursor to sulforaphane, than mature broccoli. Glucoraphanin activates the Nrf2 pathway to protect cells from oxidative stress and damage. In this episode, we describe the basics of sprouting broccoli seeds.

Posted on November 16th 2020 (about 2 years)

In this special two-hour Q&A episode with Dr. Jed Fahey, a world-leading expert on the science of chemoprotection and, in particular, sulforaphane, we discuss many of the listener-submitted questions from the hundreds of live event participants. If you're particularly fond of this format, be sure to check out our members Q&A, which happens every month.

Posted on October 13th 2020 (about 2 years)

In this episode, Dr. Giselle Petzinger discusses exciting findings in Parkinson's disease research, with an emphasis on exercise's role in neuroplasticity and delaying disease progression.

Posted on August 25th 2020 (over 2 years)

A comprehensive overview describing the nutritional and non-nutritional components of breast milk and the health benefits – to mother and infant – associated with breastfeeding.

Posted on June 10th 2020 (over 2 years)

The second in a multi-part series of COVID-19 related Q&As addressed by Rhonda Patrick, Ph.D. as a result of questions submitted by newsletter subscribers.

Posted on May 17th 2020 (over 2 years)

Dr. Rhonda Patrick makes her ninth appearance on the Joe Rogan Experience.

Posted on May 12th 2020 (over 2 years)

In this video Dr. Rhonda Patrick discusses all things vitamin C, covering oral and intravenous vitamin C bioavailability; immune cell function; protection against the common cold and other viral infections; lung function; sepsis; pneumonia; inflammation; intravenous vitamin C and cancer; effects in exercise; safety concerns, and so, so much more!

Posted on April 14th 2020 (over 2 years)

The first in a multi-part series of COVID-19 related Q&As addressed by Rhonda Patrick, Ph.D. as a result of questions submitted by newsletter subscribers.

Posted on January 29th 2020 (almost 3 years)

In this episode, Rhonda explains what NAD+, why it is so important for aging and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, what animal and human data says and some concluding thoughts.

Posted on January 8th 2020 (almost 3 years)

Dr. Rhonda Patrick visits the Kevin Rose Show to discuss metformin, magnesium L-threonate, fish oil and brain health, sulforaphane, goitrogenic activity of isothiocyanates, sauna, and more.

Posted on December 30th 2019 (almost 3 years)

The science of resveratrol including its effects in animals and humans, the mechanisms behind how it works, and the bottom line on resveratrol supplementation and safety.

Posted on November 6th 2019 (about 3 years)

David Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. His work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects.

Posted on September 10th 2019 (about 3 years)

Sauna use has emerged as a means to increase lifespan and improve overall health, based on compelling data from observational, interventional, and mechanistic studies.

Posted on August 5th 2019 (over 3 years)

Dr. Patrick discusses some of the compelling evidence that suggests exercise is a tool for preventing or managing the symptoms of depression.

Posted on June 10th 2019 (over 3 years)

Elissa Epel, PhD, is a Professor in the Department of Psychiatry at the University of California, San Francisco where she serves as the director of the Aging, Metabolism, and Emotions Center. Her research centers on the mechanisms of healthy aging and the associations between stress, telomere length, addiction, eating, and metabolic health.

Posted on April 2nd 2019 (over 3 years)

The production of melatonin begins to increase 2-3 hours before our normative bedtime, which may be a signal to the pancreas to begin suppressing the production of insulin.

Posted on March 13th 2019 (over 3 years)

Several studies have established causation showing that sleep duration is a major determinant of insulin sensitivity.

Posted on February 28th 2019 (almost 4 years)

Matthew Walker, Ph.D., is a professor of neuroscience and psychology at the University of California, Berkeley, and serves as the Director of the Center for Human Sleep Science. Formerly, Dr. Walker served as a professor of psychiatry at the Harvard Medical School. He is the author of the New York Times best-selling book _Why We Sleep: Unlocking the Power of Sleep and Dreams_.

Posted on January 17th 2019 (almost 4 years)

This episode features a Q&A session on fasting-related topics with Dr. Rhonda Patrick and Mike Maser of Zero Fasting Tracker.

Posted on October 2nd 2018 (about 4 years)

Dr. Rhonda Patrick makes her eighth appearance on the Joe Rogan Experience.

Posted on October 1st 2018 (about 4 years)

Dr. Bredesen’s is known for his work in translating his scientific research into effective treatments for Alzheimer’s disease. He is the author of the book The End of Alzheimer's and the ReCODE protocol – reversal of cognitive decline – a protocol that offers a new approach to treatment that has reversed symptoms in patients with mild cognitive impairment and Alzheimer’s disease.

Posted on August 31st 2018 (over 4 years)

This short recipe video shows a fun, tasty way to eat salmon roe. Salmon roe is rich in the omega-3 fatty acid, docosahexaenoic acid, in its phospholipid form.

Posted on July 9th 2018 (over 4 years)

Round 2 with Dr. Valter Longo. Valter Longo, PhD, is a biochemist and professor of gerontology and biological sciences at the University of Southern California (USC). He directs the USC Longevity Institute as well as the Oncology and Longevity Program at the Institute of Molecular Oncology Foundation in Milan, Italy.

Posted on March 19th 2018 (over 4 years)

Dr. Charles Raison’s research focuses on inflammation and the development of depression in response to illness and stress. He also examines the physical and behavioral effects of compassion training on the brain, inflammatory processes, and behavior as well as the effect of heat stress as a potentially therapeutic intervention major depressive disorder.

Posted on December 21st 2017 (almost 5 years)

Dr. Rhonda Patrick makes her seventh appearance on the Joe Rogan Experience.

Posted on December 13th 2017 (almost 5 years)

Eric M. Verdin, M.D. is the fifth president and chief executive officer of the Buck Institute for Research on Aging and is a professor of Medicine at UCSF.

Posted on November 27th 2017 (about 5 years)

Several associative studies that have found a link between saturated fat and heart disease... should we be concerned?

Posted on November 16th 2017 (about 5 years)

This is a video on how to plausibly increase the sulforaphane created from the glucoraphanin in your broccoli sprouts by up to 3.5-fold.

Posted on November 8th 2017 (about 5 years)

Our genes influence the way we absorb and metabolize micronutrients. Nutrigenomics looks at the influence genetic variation has over micronutrient absorption/metabolism and the biological consequences of this dynamic relationship.

Posted on November 8th 2017 (about 5 years)

In this video Dr. Rhonda Patrick shares her recipe for low-carb lemon tart and demonstrates how to make it.

Posted on November 8th 2017 (about 5 years)

Dan Pardi is a Ph.D candidate that researches sleep neurobiology at Stanford and University of Leiden. He is also co-founder of Dan’s Plan, an online wellness and technology company.

Posted on November 8th 2017 (about 5 years)

Dr. Rhonda Patrick talks about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.

Posted on October 30th 2017 (about 5 years)

It's time to abandon ad libitum! This is an almost two-hour round 2 episode with Dr. Satchin Panda focused on practical implementation of time-restricted eating, various circadian insights, and much more.

Posted on July 31st 2017 (over 5 years)

Dr. Guido Kroemer is a professor at the University of Paris Descartes and an expert in immunology, cancer biology, aging, and autophagy.

Posted on June 15th 2017 (over 5 years)

Dr. Laukkanen has been conducting long-term trials looking at the health effects of sauna use in a population of over 2,000 middle-aged men in Finland. The results? Massive reductions in mortality and memory disease in a dose-dependent fashion at 20-year follow-up.

Posted on April 28th 2017 (over 5 years)

Dr. Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging, a co-editor in chief of the _Aging Journal_ and an expert on the role of cellular senescence in the aging process and development of cancer.

Posted on April 7th 2017 (over 5 years)

Dr. Gordon Lithgow is a professor of gerontology at the Buck Institute for Research on Aging. The topic of conversation in this episode is especially focused on Dr. Lithgow's work with C. elegans, which a tiny nematode worm he uses to interrogate questions involving the aging process and lifespan extension.

Posted on March 18th 2017 (over 5 years)

What does the science say about the consumption of refined sugar? This episode covers mortality and aging, brain function, memory, neuroinflammation, development of cancer, sex hormones, addiction, & more.

Posted on March 18th 2017 (over 5 years)

Systemic inflammation is an important mechanism that research shows may have a very interesting relationship with depression.

Posted on January 19th 2017 (almost 6 years)

Dr. Jed W. Fahey is a nutritional biochemist with deep experience researching isothiocyanates like sulforaphane.

Posted on January 19th 2017 (almost 6 years)

Dr. Roland Griffiths is a clinical pharmacologist at Johns Hopkins and one of the world's foremost researchers on the psychedelic compound psilocybin.

Posted on January 19th 2017 (almost 6 years)

Dr. Rhonda Patrick makes her fifth appearance on the Joe Rogan Experience.

Posted on December 14th 2016 (almost 6 years)

This podcast is about one of the most important biological pathways you could possibly take the time to learn about: the NRF2 pathway.

Posted on October 4th 2016 (about 6 years)

Dr. Rhonda Patrick speaks with Dr. Valter Longo, a professor of gerontology and biological sciences and director of the longevity institute at the University of Southern California.

Posted on July 8th 2016 (over 6 years)

This episode features Dr. Ruth Patterson, a professor in the UC San Diego Department of Family Medicine and Public Health as well as Associate Director of Population Sciences and leader of the Cancer Prevention program at Moores Cancer Center at UC San Diego Health.

Posted on July 1st 2016 (over 6 years)

Dr. Rhonda Patrick speaks with Dr. Satchin Panda, a professor at the Salk Institute for Biological Studies in La Jolla California. Satchin's work deals specifically with the timing of food and it's relationship with our biological clocks, which are governed by a circadian rhythm.

Posted on May 31st 2016 (over 6 years)

A modest change on the "micronutrient smoothie" that also talks about the beneficial compounds that don't qualify as micronutrients.

Posted on May 4th 2016 (over 6 years)

Dr. Rhonda Patrick speaks with Ray Cronise, a former NASA material scientist and co-founder of zero gravity, a company that offers weightless parabolic flights to consumers and researchers.

Posted on April 10th 2016 (over 6 years)

This podcast is with Dr. Dominic D'Agostino, an assistant professor at the University of South Florida in Tampa and all around expert on ketosis.

Posted on March 14th 2016 (over 6 years)

Dr. Peter Attia is the founder of Attia Medical, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity and optimal performance.

Posted on February 12th 2016 (almost 7 years)

Dr. Rhonda Patrick explains how cold shock may be a type of hormesis – a stressor that, in the right dose, is enough to shock the body and kick off adaptive processes and response mechanisms that exceed what was needed to counter the initial stimuli and, ultimately, promote resilience.

Posted on January 24th 2016 (almost 7 years)

This podcast features Rich Roll. Rich is an author, a podcaster, as well as founder and first person to complete the EPIC5 Challenge.

Posted on January 3rd 2016 (almost 7 years)

Dr. Darya Rose & husband Kevin Rose join Rhonda for a chat about multi-day silent meditation retreats, Kevin's experiments with a ketogenic diet, and some ideas and other projects he's working.

Posted on January 3rd 2016 (almost 7 years)

Dr. Rhonda Patrick interviews Dr. Pierre Capel, professor emeritus in experimental immunology at the Utrecht University in the Netherlands where he researched a wide range of topics from genetic modification to cancer immunotherapy.

Posted on January 3rd 2016 (almost 7 years)

Dr. Rhonda Patrick interviews Wim Hof and discusses the 2014 study on his technique with him.

Posted on January 3rd 2016 (almost 7 years)

Dr. Rhonda Patrick delivers the keynote lecture at the Orthomolecular Medicine Congress in Bussum, Netherlands (MBOG Congres 2015). Discussion: prevalency of micronutrient inadequacy & Dr. Bruce Ames' triage theory.

Posted on January 3rd 2016 (almost 7 years)

This episode is a presentation Dr. Rhonda Patrick delivered at the Biohacker Summit in Helsinki, Finland in 2016.

Posted on January 3rd 2016 (almost 7 years)

Drs. Erica and Justin Sonnenburg both research the interaction between diet and the trillions of bacteria in the gut.

Posted on January 3rd 2016 (almost 7 years)

Ronald Krauss, M.D., is the director of atherosclerosis research at Children’s Hospital Oakland Research Institute and an adjunct professor at UCSF and UC Berkeley.

Posted on September 25th 2015 (about 7 years)

In this podcast, Rhonda discusses some of the mechanisms by which chronic stress (and rumination) affect the brain and brain aging, the gut and inflammation, the immune system, and biological aging through acceleration of telomere shortening. She talks about how meditation can buffer these negative effects of stress and improve cognitive performance, brain aging, and biological aging in general.

Posted on August 13th 2015 (over 7 years)

Dr. Aubrey de Grey is a biomedical gerontologist and the founder of the SENS research foundation which aims to find technologies that can repair the various types of damage that occur during the aging process.

Posted on July 21st 2015 (over 7 years)

Tim Ferriss, notorious self-experimenter, angel investor, startup advisor, NY Times bestselling author (3x), and much more.

Posted on July 4th 2015 (over 7 years)

Jim Kean is the CEO of National Pro Grid League (NPGL) and founder of WellnessFX.

Posted on April 28th 2015 (over 7 years)

In this video, Dr. Rhonda Patrick summarizes a recent study that found that frequency of sauna use was associated with increased decreased risk of death. Using the sauna 2-3 times per week was associated with 24% lower all-cause mortality and 4-7 times per week decreased all-cause mortality by 40%.

Posted on March 23rd 2015 (over 7 years)

This video breaks down, point-by-point what gene polymorphisms you might look at, and how they relate to very specific micronutrients.

Posted on February 12th 2015 (almost 8 years)

Is cancer just bad luck? To some degree, yes... but there's also a very, very large environmental and lifestyle component.

Posted on February 12th 2015 (almost 8 years)

Dr. Bruce Ames discusses his triage theory, which he proposes that the body has developed a rationing response to shortages of micronutrients (vitamins and minerals) throughout evolution.

Posted on December 17th 2014 (almost 8 years)

Dr. Frans Kuypers and his lab pioneered a technique that helps retrieve pluripotent stem cells from placental tissue, which is routinely needless discarded worldwide.

Posted on December 3rd 2014 (about 8 years)

Contrary to commonly held beliefs, lactate is not the cause of muscle fatigue. Rather, it's an essential source of energy itself, greedily metabolized with a greater degree of preference than many other sources of energy, including glucose. Recent research suggests that the lactate metabolic pathway plays a critical role in the context of recovery from traumatic brain injury.

Posted on October 27th 2014 (about 8 years)

Dr. Rhonda Patrick makes her third appearance on the Joe Rogan Experience.

Posted on September 29th 2014 (about 8 years)

There may be something special about sources of omega-3 that are richer in the phosphatidylcholine form of DHA.

Posted on August 5th 2014 (over 8 years)

Dr. Rhonda Patrick explains what antioxidants are, why they are important, and how they prevent DNA damage, a well-known cancer initiator.

Posted on July 22nd 2014 (over 8 years)

Dr. Terry Wahls discusses the protocol she used to reverse her secondary-progressive multiple sclerosis.

Posted on June 21st 2014 (over 8 years)

Dr. Rhonda Patrick is on The Tim Ferriss Show in episode #12 entitled "Rhonda Patrick on Life Extension, Performance, and More".

Posted on May 16th 2014 (over 8 years)

Decreased consumption of chlorophyll containing vegetables, decreased absorption, and increased excretion is largely the primary reasons why apprximately 45% of US population is deficient in magnesium.

Posted on May 16th 2014 (over 8 years)

Dr. Patrick describes how magnesium, an essential mineral that ~56% of the US population is deficient in, can help you maximize your mitochondria to increase oxidative capacity and, potentially, enhance exercise performance.

Posted on May 16th 2014 (over 8 years)

Dr. Rhonda Patrick makes her second appearance on the Joe Rogan Experience.

Posted on April 10th 2014 (over 8 years)

Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass.

Posted on February 20th 2014 (almost 9 years)

Dr. Rhonda Patrick makes her first appearance on the Joe Rogan Experience.

Posted on February 1st 2014 (almost 9 years)

In this podcast, we discuss and critically analyze a recent headline-grabbing editorial that was published in the Annals of Internal Medicine that reviewed three studies on the topic of multivitamins and chronic disease prevention. We analyze the important shortcomings of the studies and talk about the mechanism.